| Official Name: | Wortham, Missouri |
| Settlement Type: | Census-Designated Place |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | St. Francois |
| Unit Pref: | Imperial |
| Area Footnotes: | [1] |
| Area Total Km2: | 2.33 |
| Area Land Km2: | 2.31 |
| Area Water Km2: | 0.02 |
| Area Total Sq Mi: | 0.90 |
| Area Land Sq Mi: | 0.89 |
| Area Water Sq Mi: | 0.01 |
| Population As Of: | 2020 |
| Population Total: | 197 |
| Population Density Km2: | 85.34 |
| Population Density Sq Mi: | 221.10 |
| Elevation Ft: | 889 |
| Blank Name: | FIPS code |
| Blank Info: | 29-81088 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2587125 |
Wortham is a census-designated place in St. Francois County, in the U.S. state of Missouri.
Wortham was originally called "Cherrytown", and under the latter name was platted in 1904.[2] A post office called Wortham was established in 1925 and remained in operation until 1969.[3] An early postmaster, Ray Wortham, gave the community its name.