The Wolfson Baronetcy, of St. Marylebone in the City of Westminster, was one of the last baronetcies created in the Baronetcy of the United Kingdom. It was created on 19 February 1962 for Isaac Wolfson, the businessman and philanthropist who established the Wolfson Foundation. In 1985, the 2nd Baronet, Leonard Wolfson, became a life peer as Baron Wolfson, of Marylebone in the City of Westminster.