| Wiwilí | |
| Settlement Type: | Municipality |
| Other Name: | Güigüilí |
| Pushpin Map: | Nicaragua |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Nicaragua |
| Subdivision Type: | Country |
| Subdivision Name: |  Nicaragua |
| Subdivision Type1: | Department |
| Subdivision Name1: | Nueva Segovia Department |
| Unit Pref: | Imperial |
| Area Total Km2: | 398 |
| Population As Of: | 2005 |
| Population Total: | 16344 |
| Population Density Km2: | auto |
| Population Urban: | 3467 |
| Coordinates: | 13.6167°N -135°W |
Wiwilí de Nueva Segovia (pronounced as /es/) is a municipality in the Nueva Segovia Department of Nicaragua, on the west bank of the Rio Coco; Wiwilí de Jinotega is on the east bank. It borders the Bosawas National Natural Resource Reserve, the largest protected area in Central America.