Willy A. Flegel Explained

Willy A. Flegel
Birth Name:	Willy Albrecht Flegel
Birth Date:	1960 6, df=yes
Birth Place:	Dieburg, Hessen, Germany
Education:	Goethe University Frankfurt (Dr. med.)
Known For:	Rh blood group
Awards:	Philip-Levine-Preis, Germany (2004)
Module:	Embed: yes Fields: Immunohematology, Transfusion medicine

Willy Albert Flegel is a German-American medical researcher, geneticist, and physician who is best known for his work in the field of the Rh blood group.^[1] Flegel is the chief of the laboratory services section of the Department of Transfusion Medicine at the National Institutes of Health Clinical Center (NIH).^[2] He lives in Washington D.C. and Frankfurt am Main, Germany.

Early life and education

Willy Flegel was born in Dieburg, Germany,^[3] and attended Johann Wolfgang Goethe Universität in Frankfurt am Main, Germany to study medicine, where he also obtained an M.D. by research. He trained as specialist for transfusion medicine at the Universität Ulm, Germany and in molecular biology research at the University of California, San Diego. He completed his habilitation (Privatdozent) at the Universität Ulm.^[4]

Career

Flegel has medical licenses issued by the state of Hessen, Germany and the state of Maryland, and holds certification by the Board of Physicians Baden-Württemberg, specialty transfusion medicine. Clinical appointments included: chief, Department of Immunohematology at the German Red Cross Blood Service Baden-Württemberg - Hessen in Ulm for 16 years. Flegel came to the NIH Clinical Center in 2009 and remains at the NIH as the chief of the Laboratory Services Section in the Department of Transfusion Medicine.^[5]

Academic appointments

• Professor (apl. Prof.) at the Universität Ulm^[6]
  • Professor (adjunct track) at Georgetown University Medical Center, Washington D.C. Guest professor at the Huazhong University of Science and Technology, Wuhan, Hubei, China

Medical research

Flegel has received recognition for his research leading to the discovery of the molecular structure of the Rh gene locus and most of the clinically relevant molecular variants in the RHD and RHCE genes.^{[7] [8]} He proved that the weak expression of the D antigen is caused by Rh protein variants, which enabled a precision medicine approach to Rh prophylaxis in pregnancy.^[9] This work in collaboration with Franz F. Wagner refuted a scientific opinion that had been taught for decades.^[10] He showed the RHCE gene is the ancestral gene at the Rh gene locus and a gene duplication event produced the RHD gene, which encodes the D antigen in humans (Rh positive phenotype). He explained that the prevalent Rh negative phenotype in humans occurred in a subsequent gene deletion event, eliminating the RHD gene.

Other activities

Editorial boards

• Assosiate Editor, Blood Transfusion (current)
• Assosiate Editor, Transfusion (2012 - 2024)
• Senior Editor, Journal Translational Medicine (current)

Non-profit organizations

• Museum of Modern Art, Frankfurt, Member of Freunde des MUSEUM^MMK für Moderne Kunst e.V. (since 2006) ^[11]
• Friends of the Goethe-Institut Washington D.C. (FoGI, U.S. 501(c)(3) charitable organization), president, secretary, or member of the board (since 2010) ^[12]

Honors and awards ^[13]

• 2017 NIH Clinical Center CEO Award
• 2015 NIH Clinical Center Director’s Award
• 2014 Visiting Professor,^[14] Tongji Medical College, Wuhan, Hubei, China
• 2012 NIH Clinical Center Director’s Award
• 2010 NIH Clinical Center Director’s Award
• 2005 Membre d'honneur, Association Suisse de Médecine Transfusionnelle
• 2004 Philip-Levine-Preis, Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatologie^[15]

Publications ^[16]

• W. A. Flegel: Modern Rhesus (Rh) typing in transfusion and pregnancy. CMAJ 2021; 193(4):E124.
• W. A. Flegel: COVID-19: risk of infection is high, independently of ABO blood group. Haematologica 2020; 105(12): 2706-2708.
• W. A. Flegel: COVID-19 insights from transfusion medicine. British J Haematol 2020; 190(5): 715-717.
• W. A. Flegel: Mosaicism by somatic non-functional mutations: one cell lineage at a time. Haematologica. 2019; 104(3):425-427.
• W. A. Flegel: Red cell alloimmunisation: incidence and prevention. Lancet Haematol. 2016; 3(6):e260-1.
• W. A. Flegel: Pathogenesis and mechanisms of antibody-mediated hemolysis. Transfusion. 2015; 55(Suppl 2):S47-58.
• W. A. Flegel: Molecular genetics and clinical applications for RH. Transfus Apher Sci. 2011; 44(1):81-91
• W. A. Flegel: Rare gems: null phenotypes of blood groups. Blood Transfus. 2010; 8(1):2-4.
• W. A. Flegel: The Genetics of the Rhesus Blood Group System. Dtsch Ärztebl. 2007; 104(10): A-651
• W. A. Flegel: Blood group genotyping in Germany. Transfusion. 2007; 47(1 Suppl):47S-53S.
• W. A. Flegel: How I manage donors and patients with a weak D phenotype. Curr Opin Hematol. 2006; 13(6):476-83.
• H.-D. Lippert, W. A. Flegel. Kommentar zum Transfusionsgesetz (TFG) und den Hämotherapie-Richtlinien. 2002. Springer, Berlin, 521 pages. (Medical-legal textbook interpreting the code of federal regulations for transfusion medicine in Germany)
• W. A. Flegel, F. F. Wagner: Molecular genetics of RH. Vox Sang. 2000; 78(Suppl 2):109-15.
• H. Northoff, W. A. Flegel: Genotyping and phenotyping: the two sides of one coin. Infusionsther Transfusionsmed. 1999;26:5.
• W. A. Flegel, F. F. Wagner, T. H. Müller, C. Gassner: Rh phenotype prediction by DNA typing and its application to practice. Transfus Med. 1998; 8(4):281-302.
• W..A. Flegel, A. W. Singson, J. S. Margolis, A. G. Bang, J. W. Posakony, C. Murre: Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structure and developmental expression. Mech Dev 1993; 41(2-3):155-161.
• W. A. Flegel, A. Wölpl, D. N. Männel, H. Northoff: Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins. Infect Immun 1989; 57(7):2237-2245.

External links

• The phylogeny of 48 alleles, experimentally verified (YouTube-Video 2019)
• The Rhesus Site (Universität Ulm)
• Literature by W A Flegel in the catalogue of the National Library of Medicine (PubMed)
• Interview in Berlin 2010

Notes and References

1. Pierce SR, Reid ME. Bloody Brilliant! 1 ed. Bethesda MD: AABBPress, 2016. pages 577 - 579
2. https://clinicalcenter.nih.gov/meet-our-doctors/wflegel.html Chief, Laboratory Services Section at NIH Clinical Center
3. https://d-nb.info/gnd/1147009872 Katalog der Deutschen Nationalbibliothek
4. https://oparu.uni-ulm.de/xmlui/handle/123456789/129 Flegel, W.A.: Häufigkeit sporadischer nicht-funktionaler Allele und ihre Bedeutung für die Genotypisierung am Beispiel des Polymorphismus im FUT1-Blutgruppengen. Habilitationsschrift. Universität Ulm. Ulm 1997
5. Branswell H. Fresh blood no better for transfusions, Canadian-led study shows. Toronto, CA: The Canadian Press, 2015.
6. Brown AJ. Antibodies against MICA antigens linked to kidney transplant rejection. Reuters, 2007
7. Wolinsky H. A mythical beast: increased attention highlights the hidden wonders of chimeras. EMBO Rep. 2007;8: 212-4
8. Quill E. Medicine. Blood-matching goes genetic. Science 2008;319: 1478-9
9. Paxton A. Groups urge phase-in of RHD genotyping. CAP Today 2015;29: 1, 56 - 68
10. [Philip Levine (physician)|Philip-Levine]
11. https://www.mmk.art/en/about/friends-of-mmk Friends of MMK
12. https://www.goethe.de/fogi FoGI Board
13. https://clinicalcenter.nih.gov/meet-our-doctors/wflegel.html Chief, Laboratory Services Section at NIH Clinical Center
14. https://www.tjh.com.cn/html/2015/0122/14971.shtml 2014 Visiting Professor, Tongji Medical College
15. https://www.dgti.de/gesellschaft/dgti/gesellschaft/preise/philip-levine-preis Philip-Levine-Preis, Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatologie
16. https://go.usa.gov/xEwgu for a more comprehensive list of his publications in scientific journals see PubMed