| Honorific Prefix: | Honorable |
| William Wesley Mitchell Sr. | |
| State House: | Arizona |
| Office: | Arizona State House of Representative |
| Term Start: | 1937 |
| Term End: | 1958 |
| Term End2: | 1958 |
| Birth Date: | 10 October 1880 |
| Resting Place: | City of Mesa Cemetery, Mesa, Maricopa County, Arizona |
| Profession: | newspaper publisher, land developer |
William Wesley Mitchell Sr. (October 10, 1880 - April 30, 1969) was an American politician and businessman.
Born in Vienna, Illinois, Mitchell moved to Arizona Territory in 1910. He was publisher of the Mesa Free Press and was in the land development business. He served in the Arizona House of Representatives from 1937 to 1958, representing the Maricopa=11 (Phoenix) district and Maricopa-05 (Tempe) district. He died in Tempe, Arizona.