| William Thompson Nuckolls | |
| Birth Date: | 23 February 1801 |
| Birth Place: | Union County, South Carolina |
| State: | South Carolina |
| District: | 7th |
| Term Start: | March 4, 1827 |
| Term End: | March 3, 1833 |
| Predecessor: | Joseph Gist |
| Successor: | William K. Clowney |
| Party: | Jacksonian |
| Profession: | lawyer, planter |
| Alma Mater: | South Carolina College |
William Thompson Nuckolls (February 23, 1801 – September 27, 1855) was a U.S. Representative from South Carolina.
Born near Hancockville, Union (now Cherokee) County, South Carolina, Nuckolls graduated from South Carolina College (now the University of South Carolina) at Columbia in 1820.He studied law.He was admitted to the bar in 1823 and commenced practice in Spartanburg, South Carolina.
Nuckolls was elected as a Jacksonian to the Twentieth, Twenty-first, and Twenty-second Congresses (March 4, 1827 – March 3, 1833).He died on his plantation near Hancockville, South Carolina, on September 27, 1855.He was interred in Whig Hill Cemetery.