| William Stanton Pilcher | |
| Office: | 10th Mayor of Louisville, Kentucky |
| Term Start: | April 4, 1857 |
| Term End: | May 13, 1858 |
| Predecessor: | John Barbee |
| Successor: | Thomas W. Riley |
| Party: | Know Nothing |
| Birth Date: | 5 January 1803 |
| Birth Place: | Stafford County, Virginia, U.S. |
| Death Place: | Louisville, Kentucky, U.S. |
William Stanton Pilcher (January 5, 1803 – August 14, 1858) was the eleventh mayor of Louisville, Kentucky, serving from 1857 to 1858.
Pilcher was born in Stafford County, Virginia to a wealthy manufacturing family. He came to Louisville in 1833 to study law.
Pilcher unsuccessfully ran for lieutenant governor in 1844 as a Jacksonian Democrat, but was elected mayor of Louisville on the Know Nothing party on April 4, 1857, in a landslide. However, by May 13, 1858, he was too ill to continue his duties, and he died on August 14, 1858, becoming the first mayor of Louisville to die in office.[1]