| Honorific-Prefix: | Lieutenant-Colonel |
| Image Upright: | 0.65 |
| Office: | 1st Commissioner of the North-West Mounted Police |
| Term Start: | 15 September |
| Term End: | 17 October 1873 |
| Predecessor: | Office established |
| Successor: | George Arthur French |
| Allegiance: |  Canada |
| Branch: | Canadian Militia |
| Battles: | Crimean War Fenian Raids North-West Rebellion |
| Rank: | Lieutenant (UK) Lieutenant-colonel (Canada) |
| Unit: | 39th (Dorsetshire) Regiment of Foot 3rd Battalion, The Victoria Volunteer Rifles of Montreal |
| Birth Date: | 1833 |
| Birth Place: | Wales, UK |
| Death Place: | Swansea, Wales, UK |
| Commands: | 91st Winnipeg Battalion of Light Infantry |
Lieutenant-Colonel William Osborne Smith (1833 - 11 May 1887) was the first Acting Commissioner of the North-West Mounted Police, from 25 September to 17 October 1873.
Osborne Smith was born to W. H. Smith of Hendreowen (West Glamorgan), Wales. He was commissioned into the British Army's 39th Foot in 1855. He served in the Crimea and came to the province of Canada with his regiment in 1856. He married Janet Colquhoun of Montreal in 1858. When his unit was transferred to Bermuda in 1859, Osborne Smith, then a lieutenant, sold his commission and became a merchant in Montreal. He later became a lieutenant-colonel in the Canadian Militia.
Osborne Smith carries the distinction of having the only regimental number that carries a fraction. His number was 2.5.
He returned to Wales and died in Swansea in 1887.
A neighbourhood in Winnipeg is named after Osborne. The Osborne Village is part of the federal riding of Winnipeg South Centre and a major area of cultural influence, including the gay village.