| William L. Sayre High School | |
| Type: | Public high school |
| Grades: | 9–12 |
| District: | The School District of Philadelphia |
| Established: | 1949 |
| Address: | 5800 Walnut Street |
| City: | Philadelphia |
| State: | Pennsylvania |
| Country: | United States |
| Zipcode: | 19139 |
| Enrollment: | 355 (2022–23)[1] |
| Staff: | 33.20 (FTE) |
| Ratio: | 10.69 |
| Mascot: | Saber |
| Principal: | Jaime Eberle |
| Website: | Sayre High School |
William L. Sayre High School (commonly referred to as Sayre High School) is a high school in Philadelphia and a part of the School District of Philadelphia. It was founded in 1949 as a middle school serving grades 7 - 9, becoming a high school in 2003. Sayre High School is also the home site of SHIELD (Sayre Health Initiatives Education and Leadership Development), a Sayre Health Center run enrichment program providing medical assistant training, health professions education, internship employment and scholarship opportunities for School District of Philadelphia high school students.[2]