| William L. Hughes | |
| Birth Date: | 30 January 1895 |
| Birth Place: | Edgar, Nebraska, U.S. |
| Player Years1: | 1914–1916 |
| Player Team1: | Nebraska Wesleyan |
| Coach Years1: | 1924 |
| Coach Team1: | Oberlin |
| Coach Years2: | 1925–1929 |
| Coach Team2: | DePauw |
| Admin Years1: | 1925–1930 |
| Admin Team1: | DePauw |
William Leonard Hughes (born January 30, 1895) was an American college football player and coach. He was the head football coach at Oberlin College in Oberlin, Ohio in 1924[1] and DePauw University from 1925 to 1929.[2]