| William H. Murfree | |
| Birth Date: | 2 October 1781 |
| Birth Place: | Hertford County, North Carolina |
| Alma Mater: | University of North Carolina at Chapel Hill |
| State1: | North Carolina |
| District1: | 1st |
| Term Start1: | March 4, 1813 |
| Preceded1: | Lemuel Sawyer |
| Term End1: | March 3, 1817 |
| Succeeded1: | Lemuel Sawyer |
| Office2: | Member of the North Carolina General Assembly |
| Term2: | 1805 1812 |
| Party: | Democratic-Republican |
William Hardy Murfree (October 2, 1781 – January 19, 1827), born in Hertford County, North Carolina, was a member of the United States House of Representatives from North Carolina.
He graduated in 1801 from the University of North Carolina at Chapel Hill where he studied law. He was admitted to the bar and practiced in Edenton, North Carolina.
Murfee became a member of the North Carolina General Assembly in 1805 and 1812 and was elected as a Republican to the Thirteenth and Fourteenth Congresses where he served from March 4, 1813, to March 3, 1817. He served as Chairman of the Committee on Public Expenditures in the Fourteenth Congress.
In 1823, he moved from Murfreesboro, North Carolina, to his estate in Williamson County, Tennessee where he died on January 19, 1827. He was buried in Murfree Cemetery, northwest of Franklin, Tennessee. His home at Murfreesboro, North Carolina, Melrose, was listed on the National Register of Historic Places in 1971.