| William G. Holt II | |
| Allegiance: | United States |
| Branch: | United States Air Force |
| Serviceyears: | 1991–2023 |
| Rank: | Major General |
| Commands: | 352nd Special Operations Wing 319th Special Operations Squadron |
| Awards: | Air Force Distinguished Service Medal Defense Superior Service Medal Legion of Merit (3) |
William G. Holt II is a retired United States Air Force major general who last served as the vice commander of the Air University from 2021 to 2023.[1] He most recently served as the director for operations, training, and force development of the United States Space Command. Previously, he was the director of the joint space operations development for the same combatant command.[2] [3] He also served as the special assistant to the commander of the Air Force Special Operations Command.[2] In February 2021, he was assigned to replace Major General Brad M. Sullivan as vice commander of the Air University.[4]