| William Chisholm Macdonald | |
| Birthname: | William Chisholm Macdonald |
| Birth Date: | 1890 5, df=y[1] |
| Birth Place: | Bailey's Brook, Pictou County, Nova Scotia, Canada |
| Death Place: | Halifax, Nova Scotia, Canada |
| Riding: | Halifax |
| Predecessor: | Robert Emmett Finn |
| Successor: | John Dickey |
| Term Start: | March 1940 |
| Term End: | November 1946 |
| Profession: | barrister |
| Party: | Liberal |
William Chisholm Macdonald (6 May 1890 - 19 November 1946) was a Liberal party member of the House of Commons of Canada. He was born in Bailey's Brook, Nova Scotia and became a barrister by career.
He was first elected to Parliament at the Halifax riding in the 1940 general election and re-elected in 1945. Macdonald died on 19 November 1946 before completing his term in the 20th Canadian Parliament.