| William Charles Lee | |
| Office: | Senior Judge of the United States District Court for the Northern District of Indiana |
| Term Start: | February 3, 2003 |
| Term End: | January 20, 2024 |
| Office1: | Chief Judge of the United States District Court for the Northern District of Indiana |
| Term Start1: | 1997 |
| Term End1: | 2003 |
| Predecessor1: | Allen Sharp |
| Successor1: | Robert Lowell Miller Jr. |
| Office2: | Judge of the United States District Court for the Northern District of Indiana |
| Term Start2: | July 28, 1981 |
| Term End2: | February 3, 2003 |
| Appointer2: | Ronald Reagan |
| Predecessor2: | Seat established by 92 Stat. 1629 |
| Successor2: | Philip P. Simon |
| President3: | Richard Nixon |
| Term Start3: | 1970 |
| Term End3: | 1973 |
| Successor3: | John R. Wilks |
| Birth Date: | 2 February 1938 |
| Birth Place: | Fort Wayne, Indiana, U.S. |
| Education: | Yale University (AB) University of Chicago (JD) |
William Charles Lee (February 2, 1938 – January 20, 2024) was a United States district judge of the United States District Court for the Northern District of Indiana.
Born in Fort Wayne, Indiana, Lee received an Artium Baccalaureus degree from Yale University in 1959 and a Juris Doctor from the University of Chicago Law School in 1962. He was in private practice in Fort Wayne from 1962 to 1970. He was a deputy prosecuting attorney of Allen County, Indiana from 1963 to 1969. He was the United States attorney for the Northern District of Indiana from 1970 to 1973. He was in private practice in Fort Wayne from 1973 to 1981.
Lee was nominated by President Ronald Reagan on July 1, 1981, to the United States District Court for the Northern District of Indiana, to a new seat created by 92 Stat. 1629. He was confirmed by the United States Senate on July 27, 1981, and received his commission on July 28, 1981. He served as chief judge from 1997 to 2003. He assumed senior status on February 3, 2003. Lee died on January 20, 2024, at the age of 85.