Whalefall-1 RNA motif explained

Whalefall-1 RNA motif
Symbol:wf-1
Rfam:RF01762
Rna Type:sRNA
Tax Domain:Whale fall metagenome

The Whalefall-1 RNA motif (also called wf-1) refers to a conserved RNA structure that was discovered using bioinformatics.[1] [2] Structurally, the motif consists of two stem-loops (see diagram), the second of which is often terminated by a CUUG tetraloop, which is an energetically favorable RNA sequence. Whalefall-1 RNAs are found only in DNA extracted from uncultivated bacteria found on whale fall, i.e., a whale carcass. As of 2010, Whalefall-1 RNAs have not been detected in any known, cultivated species of bacteria, and are thus one of several RNAs present in environmental samples.

References

  1. Weinberg Z, Wang JX, Bogue J, etal . Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes . Genome Biol . 11 . 3 . R31 . March 2010 . 20230605 . 10.1186/gb-2010-11-3-r31 . 2864571 . free .
  2. Weinberg Z, Perreault J, Meyer MM, Breaker RR . Exceptional structured noncoding RNAs revealed by bacterial metagenome analysis . Nature . 462 . 7273 . 656–9 . December 2009 . 19956260 . 10.1038/nature08586 . 4140389. 2009Natur.462..656W .