| Official Name: | West Brule, South Dakota |
| Settlement Type: | Census-designated place |
| Pushpin Map: | South Dakota#USA |
| Pushpin Label: | West Brule |
| Coordinates: | 44.0728°N -99.6383°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Dakota |
| Subdivision Type2: | County |
| Subdivision Name2: | Lyman |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 1.18 |
| Area Land Sq Mi: | 1.18 |
| Area Water Sq Mi: | 0.00 |
| Area Total Km2: | 3.06 |
| Area Land Km2: | 3.06 |
| Area Water Km2: | 0.00 |
| Population As Of: | 2020 |
| Population Footnotes: | [2] |
| Population Density Km2: | 175.89 |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 1778 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 57548 (Lower Brule) |
| Area Code: | 605 |
| Blank Name: | FIPS code |
| Blank Info: | 46-70284 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2813043 |
| Population Total: | 538 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 455.55 |
West Brule is an unincorporated community and census-designated place (CDP) within the Lower Brule Indian Reservation in Lyman County, South Dakota, United States. It was first listed as a CDP prior to the 2020 census. The population of the CDP was 538 at the 2020 census.
It is in the northeast part of the county, 3miles west of Lower Brule and south of Lake Sharpe on the Missouri River.