| Red Clay Creek | |
| Name Other: | Tributary to White Clay Creek |
| Map Size: | 180 |
| Map Alt: | Red Clay Creek |
| Pushpin Map: | Delaware#USA |
| Pushpin Map Size: | 180 |
| Pushpin Map Caption: | Location of Red Clay Creek mouth |
| Pushpin Map Alt: | Location of Red Clay Creek mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Delaware |
| Subdivision Type3: | County |
| Subdivision Name3: | New Castle |
| Length: | 12.7miles[1] |
| Discharge1 Avg: | 74.57cuft/s at mouth with White Clay Creek[2] |
| Source1: | confluence of East and West Branches of Red Clay Creek |
| Source1 Location: | Southridge, Pennsylvania |
| Source1 Coordinates: | 39.8178°N -75.6925°W[3] |
| Source1 Elevation: | 200feet[4] |
| Mouth: | White Clay Creek |
| Mouth Location: | Stanton, Delaware |
| Mouth Coordinates: | 39.7081°N -75.6458°W[5] |
| Mouth Elevation: | 0feet[6] |
| Progression: | White Clay Creek → Christina River → Delaware River → Delaware Bay → Atlantic Ocean |
| River System: | Christina River |
| Basin Size: | [7] |
| Basin Landmarks: | Mount Cuba |
| Tributaries Left: | East Branch Red Clay Creek Burrows Run |
| Tributaries Right: | West Branch Red Clay Creek Hyde Run |
Red Clay Creek is a 12.7adj=midNaNadj=mid tributary of White Clay Creek, running through southeastern Pennsylvania and northern Delaware in the United States. As of 2000, portions of the creek are under wildlife habitat protection.
The East and West branches both rise in West Marlborough Township, Pennsylvania, near the hamlet of Upland, and flow south through Kennett Square before uniting just north of the Delaware border. The stream enters Delaware near the town of Yorklyn and flows southward through New Castle County, passing through Marshallton. Red Clay Creek empties into White Clay Creek near Stanton, approximately southwest of Wilmington. Ultimately, White Clay Creek enters the Christina River, also near Stanton.
The creek serves as a boundary between the Hundreds of Mill Creek and Christiana. The Wilmington and Western Railroad follows the creek south from Yorklyn as far as Greenbank.
In the late 19th Century, several factories were located along Red Clay Creek, including those for the manufacture of flour, wool and iron.
The creek suffered from severe flooding in 1999 due to Hurricane Floyd and in 2003 due to Tropical Storm Henri.
Since 2000, portions of the river, along with other tributaries of White Clay Creek, have been protected as part of the White Clay Creek Wild and Scenic River.