| Welsh Cup | |
| Year: | 1880–81 |
| Country: | Wales |
| Winners: | Druids |
| Second: | Newtown White Star |
| Prev Season: | 1879–80 |
| Next Season: | 1881–82 |
Source: Welsh Football Data Archive
Chirk receive a bye to the next round.
At the Racecourse Ground, Wrexham. First match was protested by Engineers regarding referee eligibility. White Star had won the first match 1–0.[1]
Source: Welsh Football Data Archive
Ruthin withdrew before replay.[2]
Source: Welsh Football Data Archive
See main article: article and 1881 Welsh Cup Final.