| Wayne Arendse | |
| Fullname: | Wayne Earl Arendse[1] |
| Height: | 1.90NaN0 |
| Birth Date: | 1984 11, df=yes |
| Birth Place: | Cape Town, South Africa |
| Position: | Central defender |
| Youthclubs1: | Kenpark United |
| Youthclubs2: | Engen Santos |
| Years1: | 2006–2012 |
| Clubs1: | Engen Santos |
| Caps1: | 162 |
| Goals1: | 3 |
| Years2: | 2012–2020 |
| Clubs2: | Mamelodi Sundowns |
| Caps2: | 106 |
| Goals2: | 5 |
| Nationalteam1: | South Africa |
| Nationalyears1: | 2012 |
| Nationalcaps1: | 1 |
| Nationalgoals1: | 0 |
Wayne Earl Arendse (born 25 November 1984) is a South African retired soccer defender. He played for Engen Santos for six years before joining Mamelodi Sundowns in July 2012.
He hails from Mitchell's Plain on the Cape Flats.
He made his debut for South Africa in 2012 and was capped once.