| Wayne Smith | |
| Birth Date: | 17 November 1979 |
| Birth Place: | Etobicoke, Ontario |
| Number: | 52 |
| Import: | no |
| Position1: | Guard |
| Position2: | Offensive tackle |
| Height Ft: | 6 |
| Height In: | 2 |
| Weight Lb: | 305 |
| College: | Appalachian State |
| High School: | McArthur |
| Cfldraftedyear: | 2004 |
| Cfldraftedround: | 1 |
| Cfldraftedpick: | 1 |
| Cfldraftedteam: | Hamilton Tiger-Cats |
| Playing Team1: | Washington Redskins |
| Playing Team2: | Denver Broncos |
| Playing Years3: | – |
| Playing Team3: | Hamilton Tiger-Cats |
| Playing Years4: | – |
| Playing Team4: | Saskatchewan Roughriders |
| Playing Team5: | Hamilton Tiger-Cats |
| Playing Years6: | – |
| Playing Team6: | Toronto Argonauts
|
| Honours: | CFLPA Pro Player All Star Team (2008)[1] |
| Cfl: | 365 |
Wayne Anthony Smith (born November 17, 1979) is a former professional Canadian football offensive lineman who played in the Canadian Football League (CFL) from 2004 to 2017. He was drafted first overall by the Hamilton Tiger-Cats in the 2004 CFL Draft and spent four seasons over two stints with the team. Smith won a Grey Cup championship with the Saskatchewan Roughriders in 2007. He was also a member of the Toronto Argonauts of the CFL and the Washington Redskins and Denver Broncos of the National Football League. He announced his retirement in April 2017.[2] He played college football at Appalachian State.