| Wandisile Simelane | |
| Birth Date: | 21 March 1998 |
| Birth Place: | Johannesburg, South Africa |
| School: | Jeppe High School for Boys |
| Position: | Centre / Wing |
| Currentclub: | / |
| Youthyears1: | 2011–2019 |
| Years1: | 2018–2019 |
| Apps1: | 5 |
| Points1: | 5 |
| Years2: | 2018–2022 |
| Apps2: | 31 |
| Points2: | 25 |
| Years3: | 2019–2022 |
| Apps3: | 30 |
| Points3: | 30 |
| Years4: | 2022– |
| Years5: | 2023– |
| Repyears1: | 2015–2016 |
| Repteam1: | South Africa U18 |
| Repcaps1: | 5 |
| Reppoints1: | 5 |
| Repyears2: | 2017–2018 |
| Repteam2: | South Africa U-20 |
| Repcaps2: | 10 |
| Reppoints2: | 40 |
| Repyears3: | 2021-present |
| Repcaps3: | 0 |
| Reppoints3: | 0 |
| Clubupdate: | 23 July 2022 |
| Repupdate: | 5 June 2021 |
Wandisile Simelane (born 21 March 1998) is a South African professional rugby union player for the in Super Rugby, the in the Currie Cup and the in the Rugby Challenge. His regular position is centre or wing.