| Wakio Mitsui | |
| Native Name Lang: | ja |
| Office: | Minister of Health, Labour and Welfare |
| Primeminister: | Yoshihiko Noda |
| Term Start: | 1 October 2012 |
| Term End: | 26 December 2012 |
| Predecessor: | Yoko Komiyama |
| Successor: | Norihisa Tamura |
| Office2: | Member of the House of Representatives |
| Constituency2: | Hokkaido PR (2000–2003) Hokkaido 2nd (2003–2012) |
| Term Start2: | 25 June 2000 |
| Term End2: | 16 November 2012 |
| Predecessor2: | Multi-member district |
| Successor2: | Takamori Yoshikawa |
| Birth Date: | 1942 11, df=yes |
| Birth Place: | Sapporo, Hokkaido, Japan |
| Death Place: | Sapporo, Hokkaido, Japan |
| Alma Mater: | Showa Pharmaceutical University |
| Party: | Democratic |
| Otherparty: | New Frontier |
was a Japanese politician of the Democratic Party of Japan, a member of the House of Representatives in the Diet (national legislature). A native of Sapporo, Hokkaido and graduate of Showa Pharmaceutical University, he was elected to the House of Representatives for the first time in 2000 after an unsuccessful run in 1996.