WT1-AS explained

In molecular biology, WT1 antisense RNA (non-protein coding), also known as WT1-AS or WIT1, is a long non-coding RNA. In humans, it is found on chromosome 11 and is expressed in kidney.^[1] It is transcribed in the opposite direction to the WT1 gene.^[2] It is functionally imprinted in the human kidney, where only the paternal allele is expressed, but not in the foetal kidney.^[3]

See also

• Long noncoding RNA

Further reading

• Hancock AL, Brown KW, Moorwood K, Moon H, Holmgren C, Mardikar SH, etal . A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. . Hum Mol Genet . 2007 . 16 . 3 . 343–354 . 17210670 . 10.1093/hmg/ddl478 . free . 10.1.1.551.9843 .

Notes and References

1. Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-MacNeill S, Coppes MJ, etal . Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. . Science . 1990 . 250 . 4983 . 991–994 . 2173145 . 10.1126/science.2173145.
2. Gessler M, Bruns GA. Sequence of the WT1 upstream region including the Wit-1 gene. . Genomics . 1993 . 17 . 2 . 499–501 . 8406502 . 10.1006/geno.1993.1355 .
3. Malik K, Salpekar A, Hancock A, Moorwood K, Jackson S, Charles A, etal . Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor. . Cancer Res . 2000 . 60 . 9 . 2356–2360 . 10811108 .