WSB1 explained

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.^{[1] [2] [3]}

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hu RM, Han ZG, Song HD, etal . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . 2000PNAS...97.9543H . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Kamura T, Burian D, Yan Q, etal . Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase . J. Biol. Chem. . 276 . 32 . 29748–53 . 2001 . 11384984 . 10.1074/jbc.M103093200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Dentice M, Bandyopadhyay A, Gereben B, etal . The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate . Nat. Cell Biol. . 7 . 7 . 698–705 . 2005 . 15965468 . 10.1038/ncb1272 . 1761694 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Woo JS, Imm JH, Min CK, etal . Structural and functional insights into the B30.2/SPRY domain . EMBO J. . 25 . 6 . 1353–63 . 2006 . 16498413 . 10.1038/sj.emboj.7600994 . 1422157 .
• Chen QR, Bilke S, Wei JS, etal . Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma . Genes Chromosomes Cancer . 45 . 9 . 856–62 . 2006 . 16804916 . 10.1002/gcc.20349 . 3099056 .

Notes and References

1. Vasiliauskas D, Hancock S, Stern CD . SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development . Mech Dev . 82 . 1–2 . 79–94 . Aug 1999 . 10354473 . 10.1016/S0925-4773(99)00014-3 . 15357835 . free .
2. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ . The SOCS box: a tale of destruction and degradation . Trends Biochem Sci . 27 . 5 . 235–41 . Jun 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 .
3. Web site: Entrez Gene: WSB1 WD repeat and SOCS box-containing 1.
4. Web site: Entrez Gene: WSB1 WD repeat and SOCS box-containing 1.