WNT11 explained

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.^{[1] [2]}

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene plays roles in the development of bones, kidneys,^[3] and lungs,^[4] and is associated with early onset osteoporosis. ^[5]

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J . Wnt family proteins are secreted and associated with the cell surface . Mol. Biol. Cell . 4 . 12 . 1267–75 . 1994 . 8167409 . 10.1091/mbc.4.12.1267. 275763 .
• Kirikoshi H, Sekihara H, Katoh M . Molecular cloning and characterization of human WNT11 . Int. J. Mol. Med. . 8 . 6 . 651–6 . 2002 . 11712081 . 10.3892/ijmm.8.6.651.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ouko L . Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells . J. Biol. Chem. . 279 . 25 . 26707–15 . 2004 . 15084607 . 10.1074/jbc.M402877200 . 1351009 . Ziegler TR . Gu LH . 3 . Eisenberg . LM . Yang . VW . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Kim SW . Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin . Nat. Cell Biol. . 6 . 12 . 1212–20 . 2005 . 15543138 . 10.1038/ncb1191 . Park JI . Spring CM . 3 . Sater . Amy K. . Ji . Hong . Otchere . Abena A. . Daniel . Juliet M. . McCrea . Pierre D. . 19404686 .
• Koyanagi M . Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells . J. Biol. Chem. . 280 . 17 . 16838–42 . 2005 . 15701629 . 10.1074/jbc.M500323200 . Haendeler J . Badorff C . 3 . Brandes . RP . Hoffmann . J . Pandur . P . Zeiher . AM . Kühl . M . Dimmeler . S . free .
• Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA . Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus . Dev. Biol. . 279 . 1 . 179–92 . 2005 . 15708567 . 10.1016/j.ydbio.2004.12.013 . free .
• Otsuki T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . Ota T . Nishikawa T . 3 . Hayashi . K . Suzuki . Y . Yamamoto . J . Wakamatsu . A . Kimura . K . Sakamoto . K . free .
• Panáková D, Werdich AA, Macrae CA . Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. . Nature . 466 . 8 . 874–878 . 2010 . 20657579. 10.1038/nature09249 . 2921013. 2010Natur.466..874P .

Notes and References

1. Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S . Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung . Gene . 219 . 1–2 . 101–10 . Dec 1998 . 9757009 . 10.1016/S0378-1119(98)00393-X .
2. Web site: Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11.
3. Majumdar . Arindam . Vainio . Seppo . Kispert . Andreas . McMahon . Jill . McMahon . Andrew P. . Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development . Development . The Company of Biologists . 130 . 14 . 2003-07-15 . 1477-9129 . 10.1242/dev.00520 . 3175–3185. 12783789 . 25866889 .
4. Lako . M . Strachan . T . Bullen . P . Wilson . D.I . Robson . S.C . Lindsay . S . Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung . Gene . Elsevier BV . 219 . 1–2 . 1998 . 0378-1119 . 10.1016/s0378-1119(98)00393-x . 101–110. 9757009 .
5. Caetano da Silva . Caroline . Edouard . Thomas . Fradin . Melanie . Aubert-Mucca . Marion . Ricquebourg . Manon . Raman . Ratish . Salles . Jean Pierre . Charon . Valérie . Guggenbuhl . Pascal . Muller . Marc . Cohen-Solal . Martine . Collet . Corinne . WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis . Human Molecular Genetics . Oxford University Press (OUP) . 31 . 10 . 2021-12-07 . 0964-6906 . 10.1093/hmg/ddab349 . 1622–1634. free . 34875064 . 9122655 .