WNT10A explained

Wnt-10a is a protein that in humans is encoded by the WNT10A gene.^{[1] [2] [3]}

Function

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.^[1]

Clinical significance

WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.^[1]

Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome^[4] and hypodontia.^[5]

Further reading

• Gelebart P, Anand M, Armanious H, etal . Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. . Blood . 112 . 13 . 5171–9 . 2008 . 18787224 . 10.1182/blood-2008-02-139212 . 2597612.
• Beaty TH, Hetmanski JB, Fallin MD, etal . Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. . Hum. Genet. . 120 . 4 . 501–18 . 2006 . 16953426 . 10.1007/s00439-006-0235-9 . 7836461 .
• Nawaz S, Klar J, Wajid M, etal . WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome. . Eur. J. Hum. Genet. . 17 . 12 . 1600–5 . 2009 . 19471313 . 10.1038/ejhg.2009.81 . 2987016.
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Medland SE, Nyholt DR, Painter JN, etal . Common variants in the trichohyalin gene are associated with straight hair in Europeans. . Am. J. Hum. Genet. . 85 . 5 . 750–5 . 2009 . 19896111 . 10.1016/j.ajhg.2009.10.009 . 2775823.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Yerges LM, Klei L, Cauley JA, etal . High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. . J. Bone Miner. Res. . 24 . 12 . 2039–49 . 2009 . 19453261 . 10.1359/jbmr.090524 . 2791518.
• Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, etal . Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia. . Leuk. Lymphoma . 50 . 12 . 2061–70 . 2009 . 19863181 . 10.3109/10428190903331082 . 38835813 .

Notes and References

1. Web site: Entrez Gene: wingless-type MMTV integration site family.
2. Kirikoshi H, Sekihara H, Katoh M . WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells . Biochem. Biophys. Res. Commun. . 283 . 4 . 798–805 . May 2001 . 11350055 . 10.1006/bbrc.2001.4855 .
3. Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de Mazancourt P, Megarbane A . Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia . Am. J. Hum. Genet. . 81 . 4 . 821–8 . October 2007 . 17847007 . 1973944 . 10.1086/520064 .
4. Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Röpke A . WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes . Am. J. Hum. Genet. . 85 . 1 . 97–105 . July 2009 . 19559398 . 2706962 . 10.1016/j.ajhg.2009.06.001 .
5. van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, Ploos van Amstel HK . Mutations in WNT10A are present in more than half of isolated hypodontia cases . J. Med. Genet. . 49 . 5 . 327–31 . May 2012 . 22581971 . 10.1136/jmedgenet-2012-100750 . 8815004 . 2019-02-16 . 2018-07-23 . https://web.archive.org/web/20180723032113/https://pure.rug.nl/ws/files/6778478/MutationsinWNT10Aarepresentinmore.pdf . dead .