WNK2 explained

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.^{[1] [2] [3]}

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.

Further reading

• Nagase T . Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 6 . 347–55 . 2001 . 11214970 . 10.1093/dnares/7.6.347 . vanc. Kikuno R . Hattori A . 3 . Kondo . Y . Okumura . K . Ohara . O . free .
• Ito M . Molecular basis of T cell-mediated recognition of pancreatic cancer cells . Cancer Res. . 61 . 5 . 2038–46 . 2001 . 11280764 . vanc. Shichijo S . Tsuda N . 3 . Ochi . M . Harashima . N . Saito . N . Itoh . K .
• Wilson FH . Human hypertension caused by mutations in WNK kinases . Science . 293 . 5532 . 1107–12 . 2001 . 11498583 . 10.1126/science.1062844 . vanc. Disse-Nicodème S . Choate KA . 3 . Ishikawa . K . Nelson-Williams . C . Desitter . I . Gunel . M . Milford . DV . Lipkin . GW . 22700809 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Moniz S . Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2 . Oncogene . 26 . 41 . 6071–81 . 2007 . 17667937 . 10.1038/sj.onc.1210706 . vanc. Veríssimo F . Matos P . 3 . Brazão . R . Silva . E . Kotevelets . L . Chastre . E . Gespach . C . Jordan . P . free .

Notes and References

1. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ . Characterization of human colon cancer antigens recognized by autologous antibodies . Int J Cancer . 76 . 5 . 652–8 . Jun 1998 . 9610721 . 10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P . free .
2. Verissimo F, Jordan P . WNK kinases, a novel protein kinase subfamily in multi-cellular organisms . Oncogene . 20 . 39 . 5562–9 . Sep 2001 . 11571656 . 10.1038/sj.onc.1204726 . free .
3. Web site: Entrez Gene: WNK2 WNK lysine deficient protein kinase 2.