WIPF2 explained

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.^{[1] [2] [3]}

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Salazar MA, Kwiatkowski AV, Pellegrini L, etal . Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton . J. Biol. Chem. . 278 . 49 . 49031–43 . 2004 . 14506234 . 10.1074/jbc.M308104200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wan D, Gong Y, Qin W, etal . Large-scale cDNA transfection screening for genes related to cancer development and progression . Proc. Natl. Acad. Sci. U.S.A. . 101 . 44 . 15724–9 . 2004 . 15498874 . 10.1073/pnas.0404089101 . 524842 . 2004PNAS..10115724W . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Aspenstrom P . The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor . Exp Cell Res . 279 . 1 . 21–33 . Sep 2002 . 12213210 . 10.1006/excr.2002.5576 .
2. Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T . WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation . Biochem Biophys Res Commun . 291 . 1 . 41–7 . Feb 2002 . 11829459 . 10.1006/bbrc.2002.6406 .
3. Web site: Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2.