WFIKKN2 explained

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene.^[1]

Function

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY358142.1, AK127743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025083, ERS025084 [ECO:0000348] ##Evidence-Data-END##

See also

• Kazal-type serine protease inhibitor domain

Further reading

• Szláma G, Kondás K, Trexler M, Patthy L . WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity . The FEBS Journal . 277 . 24 . 5040–50 . December 2010 . 21054789 . 10.1111/j.1742-4658.2010.07909.x . 45602047 . free .
• Hill JJ, Qiu Y, Hewick RM, Wolfman NM . Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains . Molecular Endocrinology . 17 . 6 . 1144–54 . June 2003 . 12595574 . 10.1210/me.2002-0366 . free .
• Kondás K, Szláma G, Trexler M, Patthy L . Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11 . The Journal of Biological Chemistry . 283 . 35 . 23677–84 . August 2008 . 18596030 . 3259755 . 10.1074/jbc.M803025200 . free .
• Nagy A, Trexler M, Patthy L . Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein . European Journal of Biochemistry . 270 . 9 . 2101–7 . May 2003 . 12709070 . 10.1046/j.1432-1033.2003.03593.x . free .
• Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET . Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women . Journal of Strength and Conditioning Research . 26 . 5 . 1374–82 . May 2012 . 22395277 . 10.1519/JSC.0b013e318251083f . 12311653 . free .
• Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K . Effects of oral creatine and resistance training on serum myostatin and GASP-1 . Molecular and Cellular Endocrinology . 317 . 1–2 . 25–30 . April 2010 . 20026378 . 10.1016/j.mce.2009.12.019 . 25180090 .
• Trexler M, Bányai L, Patthy L . Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules . Biological Chemistry . 383 . 1 . 223–8 . January 2002 . 11928817 . 10.1515/BC.2002.023 . 37069938 .

Notes and References

1. Web site: Entrez Gene: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 .