WFIKKN1 explained

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.^{[1] [2]} when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.^[3]

Further reading

• Liepinsh E, Nagy A, Trexler M, etal . Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein . J. Biomol. NMR . 35 . 1 . 73–8 . 2006 . 16791741 . 10.1007/s10858-006-9013-1 . 34083234 .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Nagy A, Trexler M, Patthy L . Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein . Eur. J. Biochem. . 270 . 9 . 2101–7 . 2003 . 12709070 . 10.1046/j.1432-1033.2003.03593.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .

Notes and References

1. Trexler M, Banyai L, Patthy L . A human protein containing multiple types of protease-inhibitory modules . Proc Natl Acad Sci U S A . 98 . 7 . 3705–9 . Mar 2001 . 11274388 . 31116 . 10.1073/pnas.061028398 . 2001PNAS...98.3705T . free .
2. Trexler M, Banyai L, Patthy L . Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules . Biol Chem . 383 . 1 . 223–8 . Apr 2002 . 11928817 . 10.1515/BC.2002.023 . 37069938 .
3. Web site: Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1.