WFDC1 explained

WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene.^{[1] [2]}

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.

Further reading

• Alvarez R, Reading J, King DF, etal . WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection. . J. Virol. . 82 . 1 . 471–86 . 2008 . 17942534 . 10.1128/JVI.00939-07 . 2224370 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Watson JE, Kamkar S, James K, etal . Molecular analysis of WFDC1/ps20 gene in prostate cancer. . Prostate . 61 . 2 . 192–9 . 2004 . 15305342 . 10.1002/pros.20100 . 24557545 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• McAlhany SJ, Ressler SJ, Larsen M, etal . Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. . Cancer Res. . 63 . 18 . 5859–65 . 2003 . 14522910 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Saffroy R, Riou P, Soler G, etal . Analysis of alterations of WFDC1, a new putative tumour suppressor gene, in hepatocellular carcinoma. . Eur. J. Hum. Genet. . 10 . 4 . 239–44 . 2002 . 12032731 . 10.1038/sj.ejhg.5200795 . free .

Notes and References

1. Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR . The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers . Mamm Genome . 11 . 9 . 767–73 . Sep 2000 . 10967136 . 10.1007/s003350010135 . 2474630 .
2. Web site: Entrez Gene: WFDC1 WAP four-disulfide core domain 1.