WDR8 explained

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.^[1]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification (osteogenesis).^[1]

Further reading

• Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y . Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family . Genomics . 72 . 3 . 252–9 . March 2001 . 11401440 . 10.1006/geno.2000.6475 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Web site: Entrez Gene: WDR8 WD repeat domain 8.