WD repeat-containing protein 77 explained

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.^{[1] [2] [3]}

Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1^[4] and Protein arginine methyltransferase 5.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Licciardo P, Amente S, Ruggiero L, etal . The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP. . Nucleic Acids Res. . 31 . 3 . 999–1005 . 2003 . 12560496 . 10.1093/nar/gkg197 . 149217 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Yamada S, Ohira M, Horie H, etal . Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. . Oncogene . 23 . 35 . 5901–11 . 2004 . 15221005 . 10.1038/sj.onc.1207782 . 3114318 .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Amente S, Napolitano G, Licciardo P, etal . Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation. . FEBS Lett. . 579 . 3 . 683–9 . 2005 . 15670829 . 10.1016/j.febslet.2004.12.045 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Furuno K, Masatsugu T, Sonoda M, etal . Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. . Biochem. Biophys. Res. Commun. . 345 . 3 . 1051–8 . 2006 . 16712789 . 10.1016/j.bbrc.2006.05.014 .
• Zhou L, Wu H, Lee P, Wang Z . Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells. . J. Mol. Endocrinol. . 37 . 2 . 283–300 . 2007 . 17032745 . 10.1677/jme.1.02062 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Liang JJ, Wang Z, Chiriboga L, etal . The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. . J. Urol. . 177 . 5 . 1918–22 . 2007 . 17437848 . 10.1016/j.juro.2007.01.017 .

• Rengasamy, M, Zhang, F, Vashisht, A, Song, WM, etal . The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer. . Nucleic Acids Res. . 45 . 19 . 11106–11120 . 2017 . 28977470 . 10.1093/nar/gkx727. 5737218 . free .

Notes and References

1. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G . A novel WD repeat protein component of the methylosome binds Sm proteins . J Biol Chem . 277 . 10 . 8243–7 . Mar 2002 . 11756452 . 10.1074/jbc.M109984200 . free .
2. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal Biochem . 236 . 1 . 107–13 . Jun 1996 . 8619474 . 10.1006/abio.1996.0138 .
3. Web site: Entrez Gene: WDR77 WD repeat domain 77.
4. 10.1093/nar/gkg197 . Licciardo . Paolo . Amente Stefano . Ruggiero Luca . Monti Maria . Pucci Piero . Lania Luigi . Majello Barbara . Feb 2003 . The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP . Nucleic Acids Res. . 31 . 3 . 999–1005 . England. 12560496 . 149217 .