WDR68 explained

WD repeat-containing protein 68 is a protein that in humans is encoded by the DCAF7 gene.^{[1] [2]}

Interactions

WDR68 has been shown to interact with DYRK1A.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Skurat AV, Dietrich AD . Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases . J. Biol. Chem. . 279 . 4 . 2490–8 . 2004 . 14593110 . 10.1074/jbc.M301769200 . free .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Morita K, Lo Celso C, Spencer-Dene B, Zouboulis CC, Watt FM . HAN11 binds mDia1 and controls GLI1 transcriptional activity . J. Dermatol. Sci. . 44 . 1 . 11–20 . 2006 . 16887337 . 10.1016/j.jdermsci.2006.06.001 .
• Nissen RM, Amsterdam A, Hopkins N . A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression . BMC Dev. Biol. . 6 . 28 . 28 . 2006 . 16759393 . 1523201 . 10.1186/1471-213X-6-28 . free .
• Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, Nissen RM . The zebrafish dyrk1b gene is important for endoderm formation . Genesis . 48 . 1 . 20–30 . 2010 . 20014342 . 2806492 . 10.1002/dvg.20578 .
• Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML . The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions . EMBO J. . 29 . 22 . 3750–61 . 2010 . 20940704 . 2989105 . 10.1038/emboj.2010.251 .

Notes and References

1. de Vetten N, Quattrocchio F, Mol J, Koes R . The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals . Genes Dev. . 11 . 11 . 1422–34 . Jul 1997 . 9192870 . 10.1101/gad.11.11.1422 . free .
2. Web site: Entrez Gene: WDR68 WD repeat domain 68.
3. Skurat AV, Dietrich AD . Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases . J. Biol. Chem. . 279 . 4 . 2490–8 . Jan 2004 . 14593110 . 10.1074/jbc.M301769200 . free .