WDR6 explained

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.^[1]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is ubiquitously expressed in adult and fetal tissues.

Further reading

• Li D, Roberts R . WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases . Cell. Mol. Life Sci. . 58 . 14 . 2085–97 . 2002 . 11814058 . 10.1007/PL00000838 . 20646422 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . Akira . Sugano . Sumio .
• Li D . Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene . Biochem. Biophys. Res. Commun. . 274 . 1 . 117–23 . 2000 . 10903905 . 10.1006/bbrc.2000.3012 . vanc. Burch P . Gonzalez O . 3 . Kashork . Catherine D. . Shaffer . Lisa G. . Bachinski . Linda L. . Roberts . Robert .
• Sano H . Insulin receptor substrate 4 associates with the protein IRAS . J. Biol. Chem. . 277 . 22 . 19439–47 . 2002 . 11912194 . 10.1074/jbc.M111838200 . vanc. Liu SC . Lane WS . 3 . Piletz . JE . Lienhard . GE . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Xie X, Wang Z, Chen Y . Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction . Mol. Cell. Biochem. . 301 . 1–2 . 115–22 . 2007 . 17216128 . 10.1007/s11010-006-9402-5 . 25503392 .

Notes and References

1. Web site: Entrez Gene: WDR6 WD repeat domain 6.