WDR57 explained

WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.^[1]

Function

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.^[1]

Interactions

WDR57 has been shown to interact with PRPF8^{[2] [3]} and EFTUD2.^{[2] [3]}

Further reading

• Turner IA, Norman CM, Churcher MJ, Newman AJ . Roles of the U5 snRNP in spliceosome dynamics and catalysis . Biochemical Society Transactions . 32 . Pt 6 . 928–31 . Dec 2004 . 15506927 . 10.1042/BST0320928 .
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M . Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex . Nature Genetics . 20 . 1 . 46–50 . Sep 1998 . 9731529 . 10.1038/1700 . 585778 .
• Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R . The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein . Molecular and Cellular Biology . 18 . 11 . 6756–66 . Nov 1998 . 9774689 . 109259 . 10.1128/mcb.18.11.6756.
• Makarov EM, Makarova OV, Achsel T, Lührmann R . The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions . Journal of Molecular Biology . 298 . 4 . 567–75 . May 2000 . 10788320 . 10.1006/jmbi.2000.3685 .
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . Apr 2002 . 11991638 . 1370266 . 10.1017/S1355838202021088 .
• Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V . Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy . Nature Genetics . 38 . 2 . 197–202 . Feb 2006 . 16429158 . 10.1038/ng1727 . 16668375 .
• Liu S, Rauhut R, Vornlocher HP, Lührmann R . The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP . RNA . 12 . 7 . 1418–30 . Jul 2006 . 16723661 . 1484429 . 10.1261/rna.55406 .
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H . CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation . Nature Cell Biology . 8 . 11 . 1277–83 . Nov 2006 . 17041588 . 10.1038/ncb1490 . 10397/34293 . 22180568 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Web site: Entrez Gene: WDR57 WD repeat domain 57 (U5 snRNP specific).
2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
3. Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R . The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein . Molecular and Cellular Biology . 18 . 11 . 6756–66 . Nov 1998 . 9774689 . 109259 . 10.1128/mcb.18.11.6756.