WDR36 explained

WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene.^{[1] [2] [3]}

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Mao M, Biery MC, Kobayashi SV, etal . T lymphocyte activation gene identification by coregulated expression on DNA microarrays . Genomics . 83 . 6 . 989–99 . 2005 . 15177553 . 10.1016/j.ygeno.2003.12.019 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Pang CP, Fan BJ, Canlas O, etal . A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q . Mol. Vis. . 12 . 85–92 . 2006 . 16518310 .
• Hauser MA, Allingham RR, Linkroum K, etal . Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma . Invest. Ophthalmol. Vis. Sci. . 47 . 6 . 2542–6 . 2006 . 16723468 . 10.1167/iovs.05-1476 .
• Hewitt AW, Dimasi DP, Mackey DA, Craig JE . A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant . Am. J. Ophthalmol. . 142 . 2 . 324–5 . 2006 . 16876519 . 10.1016/j.ajo.2006.02.041 .
• Kramer PL, Samples JR, Monemi S, etal . The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region . Arch. Ophthalmol. . 124 . 9 . 1328–31 . 2006 . 16966629 . 10.1001/archopht.124.9.1328 .
• Weisschuh N, Wolf C, Wissinger B, Gramer E . Variations in the WDR36 gene in German patients with normal tension glaucoma . Mol. Vis. . 13 . 724–9 . 2007 . 17563723 . 2765470 .
• Miyazawa A, Fuse N, Mengkegale M, etal . Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese . Mol. Vis. . 13 . 1912–9 . 2007 . 17960130 .

Notes and References

1. . The small-subunit processome is a ribosome assembly intermediate . Eukaryot Cell . 3 . 6 . 1619–26 . Dec 2004 . 15590835 . 539036 . 10.1128/EC.3.6.1619-1626.2004 .
2. Monemi S, Spaeth G, DaSilva A, Popinchalk S, Ilitchev E, Liebmann J, Ritch R, Heon E, Crick RP, Child A, Sarfarazi M . Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1 . Hum Mol Genet . 14 . 6 . 725–33 . Mar 2005 . 15677485 . 10.1093/hmg/ddi068 . free . 10.1.1.542.5801 .
3. Web site: Entrez Gene: WDR36 WD repeat domain 36.