WDR3 explained

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.^{[1] [2]}

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

Further reading

• Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherl A, Couté Y, Déon C, etal . Functional proteomic analysis of human nucleolus . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free .
• Claudio JO, Liew CC, Dempsey AA, etal . Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy . Genomics . 50 . 1 . 44–52 . 1999 . 9628821 . 10.1006/geno.1998.5308 .

Notes and References

1. Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG . Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13 . Genomics . 59 . 1 . 85–9 . Aug 1999 . 10395803 . 10.1006/geno.1999.5858 .
2. Web site: Entrez Gene: WDR3 WD repeat domain 3.