DCAF11 explained

DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.^[1] WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.^[2]

Further reading

• Siswanto FM, Oguro A, Arase S, Imaoka S . WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes . Drug Metabolism and Pharmacokinetics . 35 . 5 . 441–455 . October 2020 . 32839090 . 10.1016/j.dmpk.2020.06.007 . 221307354 .
• Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, Kinsella TM, Simon GM, Baltgalvis KA, Cravatt BF . 6 . DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras . Journal of the American Chemical Society . 143 . 13 . 5141–5149 . April 2021 . 33783207 . 10.1021/jacs.1c00990 . 8309050 .
• Le R, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, Li Z, Guo M, Kou X, Zhao Y, Chen M, Zhu Q, Zhao A, Yin J, Sun J, Su Z, Shi K, Gao Y, Chen J, Liu W, Kang L, Wang Y, Li C, Liu X, Gao R, Wang H, Ju Z, Gao S . 6 . Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells . Cell Stem Cell . 28 . 4 . 732–747.e9 . April 2021 . 33357405 . 10.1016/j.stem.2020.11.018 . 229693249 . free .
• Wang K, Liu Y, Yu Z, Gu B, Hu J, Huang L, Ge X, Xu L, Zhang M, Zhao J, Hu M, Le R, Wu Q, Ye S, Gao S, Zhang X, Xu RM, Li G . 6 . Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle . Cell Reports . 37 . 6 . 109987 . November 2021 . 34758320 . 10.1016/j.celrep.2021.109987 . 243952009 . free .
• Siswanto FM, Sakuma R, Oguro A, Imaoka S . Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f . The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences . 77 . 8 . 1503–1516 . August 2022 . 35279029 . 10.1093/gerona/glac062 .

Notes and References

1. Choe KP, Przybysz AJ, Strange K . The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans . Molecular and Cellular Biology . 29 . 10 . 2704–2715 . May 2009 . 19273594 . 10.1128/MCB.01811-08 . 2682033 .
2. Spatola BN, Lo JY, Wang B, Curran SP . August 2019 . Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates . Scientific Reports . 9 . 1 . 11783 . 2019NatSR...911783S . 10.1038/s41598-019-48286-y . 6692315 . 31409866.