WBP2 explained

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.^{[1] [2]}

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.

Further reading

• Pirozzi G, McConnell SJ, Uveges AJ, etal . Identification of novel human WW domain-containing proteins by cloning of ligand targets . J. Biol. Chem. . 272 . 23 . 14611–6 . 1997 . 9169421 . 10.1074/jbc.272.23.14611 . free .
• Chen HI, Einbond A, Kwak SJ, etal . Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands . J. Biol. Chem. . 272 . 27 . 17070–7 . 1997 . 9202023 . 10.1074/jbc.272.27.17070 . free .
• Jolliffe CN, Harvey KF, Haines BP, etal . Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 . Biochem. J. . 351 . 3. 557–65 . 2001 . 11042109 . 10.1042/0264-6021:3510557. 1221394 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nitsch R, Di Palma T, Mascia A, Zannini M . WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8 . Biochem. J. . 377 . Pt 3 . 553–60 . 2004 . 14531730 . 10.1042/BJ20031233 . 1223889 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tao WA, Wollscheid B, O'Brien R, etal . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry . Nat. Methods . 2 . 8 . 591–8 . 2005 . 16094384 . 10.1038/nmeth776 . 20475874 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Dhananjayan SC, Ramamoorthy S, Khan OY, etal . WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors . Mol. Endocrinol. . 20 . 10 . 2343–54 . 2006 . 16772533 . 10.1210/me.2005-0533 . free .

Notes and References

1. Chen HI, Sudol M . The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules . Proc Natl Acad Sci U S A . 92 . 17 . 7819–23 . Sep 1995 . 7644498 . 41237 . 10.1073/pnas.92.17.7819 . 1995PNAS...92.7819C . free .
2. Web site: Entrez Gene: WBP2 WW domain binding protein 2.