WBP1 explained

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.^{[1] [2]}

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ludes-Meyers JH, Kil H, Bednarek AK, etal . WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins . Oncogene . 23 . 29 . 5049–55 . 2004 . 15064722 . 10.1038/sj.onc.1207680 . 4143251 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jolliffe CN, Harvey KF, Haines BP, etal . Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4 . Biochem. J. . 351 Pt 3 . 3. 557–65 . 2001 . 11042109 . 10.1042/0264-6021:3510557. 1221394 .
• Chen HI, Einbond A, Kwak SJ, etal . Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands . J. Biol. Chem. . 272 . 27 . 17070–7 . 1997 . 9202023 . 10.1074/jbc.272.27.17070 . free .
• Pirozzi G, McConnell SJ, Uveges AJ, etal . Identification of novel human WW domain-containing proteins by cloning of ligand targets . J. Biol. Chem. . 272 . 23 . 14611–6 . 1997 . 9169421 . 10.1074/jbc.272.23.14611 . free .

Notes and References

1. Chen HI, Sudol M . The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules . Proc Natl Acad Sci U S A . 92 . 17 . 7819–23 . Sep 1995 . 7644498 . 41237 . 10.1073/pnas.92.17.7819 . 1995PNAS...92.7819C . free .
2. Web site: Entrez Gene: WBP1 WW domain binding protein 1.