WAY-213,613 explained

WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT2, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.[1] It is used in scientific research into the function of the glutamate transporters.[2]

Notes and References

  1. Dunlop J, McIlvain HB, Carrick TA, Jow B, Lu Q, Kowal D, Lin S, Greenfield A, Grosanu C, Fan K, Petroski R, Williams J, Foster A, Butera J . 6 . Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2 . Molecular Pharmacology . 68 . 4 . 974–82 . October 2005 . 16014807 . 10.1124/mol.105.012005 . 24207924 .
  2. Karatas-Wulf U, Koepsell H, Bergert M, Sönnekes S, Kugler P . Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells . Neuroscience . 161 . 3 . 794–805 . July 2009 . 19364521 . 10.1016/j.neuroscience.2009.04.017 . 23641405 .

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