WAY-163909 explained

WAY-163,909 is a drug which acts as a potent and reasonably selective agonist for the serotonin 5-HT_2C receptor.^{[1] [2]} It has antipsychotic-like effects in animal models,^{[3] [4]} and has been used to study the role of the 5-HT_2C receptor subtype in the action of addictive drugs such as nicotine and methamphetamine.^{[5] [6]}

See also

• IHCH-7113
• Lorcaserin
• Ro60-0213
• Vabicaserin
• VER-3323
• WAY-470
• YM-348

Notes and References

1. Dunlop J, Sabb AL, Mazandarani H, Zhang J, Kalgaonker S, Shukhina E, Sukoff S, Vogel RL, Stack G, Schechter L, Harrison BL, Rosenzweig-Lipson S . 6 . WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity . The Journal of Pharmacology and Experimental Therapeutics . 313 . 2 . 862–9 . May 2005 . 15705738 . 10.1124/jpet.104.075382 . 767189 .
2. Dunlop J, Marquis KL, Lim HK, Leung L, Kao J, Cheesman C, Rosenzweig-Lipson S . Pharmacological profile of the 5-HT(2C) receptor agonist WAY-163909; therapeutic potential in multiple indications . CNS Drug Reviews . 2006 . 12 . 3–4 . 167–77 . 17227285 . 10.1111/j.1527-3458.2006.00167.x . 6506193 .
3. Marquis KL, Sabb AL, Logue SF, Brennan JA, Piesla MJ, Comery TA, Grauer SM, Ashby CR, Nguyen HQ, Dawson LA, Barrett JE, Stack G, Meltzer HY, Harrison BL, Rosenzweig-Lipson S . 6 . WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity . The Journal of Pharmacology and Experimental Therapeutics . 320 . 1 . 486–96 . January 2007 . 17038512 . 10.1124/jpet.106.106989 . 40512921 .
4. Grauer SM, Graf R, Navarra R, Sung A, Logue SF, Stack G, Huselton C, Liu Z, Comery TA, Marquis KL, Rosenzweig-Lipson S . 6 . WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics . Psychopharmacology . 204 . 1 . 37–48 . May 2009 . 19107466 . 10.1007/s00213-008-1433-z . 27417671 .
5. Zaniewska M, McCreary AC, Przegaliński E, Filip M . Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats . European Journal of Pharmacology . 571 . 2–3 . 156–65 . October 2007 . 17617403 . 10.1016/j.ejphar.2007.05.067 .
6. Odabas-Geldiay M, Shields H, Berro LF, Rice KC, Howell LL . Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys . Drug and Alcohol Dependence . 194 . 252–256 . January 2019 . 30469095 . 10.1016/j.drugalcdep.2018.10.018 . 6312465 .