WAY-161503 explained

WAY-161503 is a full agonist of 5-HT_2C receptors (Ki = 3.3 nM for displacement of DOI), ~6-fold less potent at 5-HT_2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT_2B receptors (Ki = 60 nM). In functional studies, it stimulates calcium mobilization coupled to 5-HT_2C, 5-HT_2B, and 5-HT_2A receptors with EC₅₀ values of 0.8, 1.8, and 7 nM, respectively. WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED₅₀ values of 1.9, 6.8, and 0.73 mg/kg, respectively.^[1]

WAY-161503 has been used to examine the role of 5-HT_2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.^{[2] [3]}

Notes and References

1. Rosenzweig-Lipson S, Zhang J, Mazandarani H, Harrison BL, Sabb A, Sabalski J, Stack G, Welmaker G, Barrett JE, Dunlop J . 6 . Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503 . Brain Research . 1073-1074 . 240–51 . February 2006 . 16430874 . 10.1016/j.brainres.2005.12.052 . 23160473 .
2. Cryan JF, Lucki I . Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors . The Journal of Pharmacology and Experimental Therapeutics . 295 . 3 . 1120–6 . December 2000 . 11082448 .
3. Hayes DJ, Mosher TM, Greenshaw AJ . Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats . Behavioural Brain Research . 197 . 2 . 323–30 . February 2009 . 18805442 . 10.1016/j.bbr.2008.08.034 . 16911749 .