WASF3 explained

Wiskott–Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.^{[1] [2]}

This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to transduce signals that involve changes in cell shape, motility or function.

See also

• WASp (encoded by WAS gene)
• WASF1
• WASF2

Further reading

• Jones GE . Cellular signaling in macrophage migration and chemotaxis . J. Leukoc. Biol. . 68 . 5 . 593–602 . 2000 . 10.1189/jlb.68.5.593 . 11073096 . 14783521 .
• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Schott DR, Chang JN, Deng G, etal . A candidate tumor suppressor gene in human breast cancers . Cancer Res. . 54 . 6 . 1393–6 . 1994 . 8137235 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Bear JE, Rawls JF, Saxe CL . SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development . J. Cell Biol. . 142 . 5 . 1325–35 . 1998 . 9732292 . 10.1083/jcb.142.5.1325 . 2149354 .
• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 6 . 355–64 . 1999 . 10048485 . 10.1093/dnares/5.6.355 . free .
• Marchand JB, Kaiser DA, Pollard TD, Higgs HN . Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex . Nat. Cell Biol. . 3 . 1 . 76–82 . 2001 . 11146629 . 10.1038/35050590 . 30437883 .
• Millard TH, Machesky LM . The Wiskott–Aldrich syndrome protein (WASP) family . Trends Biochem. Sci. . 26 . 3 . 198–9 . 2001 . 11246027 . 10.1016/S0968-0004(01)01788-1 .
• Sossey-Alaoui K, Su G, Malaj E, etal . WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma . Oncogene . 21 . 38 . 5967–74 . 2002 . 12185600 . 10.1038/sj.onc.1205734 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Sossey-Alaoui K, Head K, Nowak N, Cowell JK . Genomic organization and expression profile of the human and mouse WAVE gene family . Mamm. Genome . 14 . 5 . 314–22 . 2003 . 12856283 . 10.1007/s00335-002-2247-7 . 1042966 .
• Dunham A, Matthews LH, Burton J, etal . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D .
• Oda A, Miki H, Wada I, etal . WAVE/Scars in platelets . Blood . 105 . 8 . 3141–8 . 2005 . 15280206 . 10.1182/blood-2003-04-1319 . 6674815 . free .
• Kashiwagi H, Shiraga M, Kato H, etal . Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage . J. Thromb. Haemost. . 3 . 2 . 361–8 . 2005 . 15670045 . 10.1111/j.1538-7836.2004.01082.x . free .
• Stovold CF, Millard TH, Machesky LM . Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2 . BMC Cell Biol. . 6 . 1 . 11 . 2006 . 15752430 . 10.1186/1471-2121-6-11 . 555569 . free .
• Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK . WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase . J. Biol. Chem. . 280 . 23 . 21748–55 . 2005 . 15826941 . 10.1074/jbc.M500503200 . free .
• Sossey-Alaoui K, Ranalli TA, Li X, etal . WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression . Exp. Cell Res. . 308 . 1 . 135–45 . 2005 . 15907837 . 10.1016/j.yexcr.2005.04.011 .

Notes and References

1. Suetsugu S, Miki H, Takenawa T . Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex . Biochem Biophys Res Commun . 260 . 1 . 296–302 . Jul 1999 . 10381382 . 10.1006/bbrc.1999.0894 .
2. Web site: Entrez Gene: WASF3 WAS protein family, member 3.