WASF2 explained

Wiskott–Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.^[1]

This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location^[2] has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.^[3]

Interactions

WASF2 has been shown to interact with BAIAP2.^[4]

Further reading

• Jones GE . Cellular signaling in macrophage migration and chemotaxis. . J. Leukoc. Biol. . 68 . 5 . 593–602 . 2000 . 10.1189/jlb.68.5.593 . 11073096 . 14783521 .
• She HY, Rockow S, Tang J, etal . Wiskott–Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. . Mol. Biol. Cell . 8 . 9 . 1709–21 . 1997 . 9307968 . 10.1091/mbc.8.9.1709. 305731 .
• Bear JE, Rawls JF, Saxe CL . SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. . J. Cell Biol. . 142 . 5 . 1325–35 . 1998 . 9732292 . 10.1083/jcb.142.5.1325 . 2149354 .
• Wu Y, Dowbenko D, Lasky LA . PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. . J. Biol. Chem. . 273 . 46 . 30487–96 . 1998 . 9804817 . 10.1074/jbc.273.46.30487 . free .
• Machesky LM, Insall RH . Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. . Curr. Biol. . 8 . 25 . 1347–56 . 1999 . 9889097 . 10.1016/S0960-9822(98)00015-3 . 16661755 . free .
• Qualmann B, Roos J, DiGregorio PJ, Kelly RB . Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott–Aldrich syndrome protein. . Mol. Biol. Cell . 10 . 2 . 501–13 . 1999 . 9950691 . 10.1091/mbc.10.2.501. 25183 .
• Stewart DM, Tian L, Nelson DL . Mutations that cause the Wiskott–Aldrich syndrome impair the interaction of Wiskott–Aldrich syndrome protein (WASP) with WASP interacting protein. . J. Immunol. . 162 . 8 . 5019–24 . 1999 . 10.4049/jimmunol.162.8.5019 . 10202051 . free .
• Morrogh LM, Hinshelwood S, Costello P, etal . The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro. . Eur. J. Immunol. . 29 . 7 . 2269–79 . 1999 . 10427990 . 10.1002/(SICI)1521-4141(199907)29:07<2269::AID-IMMU2269>3.0.CO;2-# . 13780011 .
• Banin S, Gout I, Brickell P . Interaction between Wiskott–Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase. . Mol. Biol. Rep. . 26 . 3 . 173–7 . 1999 . 10532312 . 10.1023/A:1006954206151 . 36018089 .
• Westphal RS, Soderling SH, Alto NM, etal . Scar/WAVE-1, a Wiskott–Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. . EMBO J. . 19 . 17 . 4589–600 . 2000 . 10970852 . 10.1093/emboj/19.17.4589 . 302050 .
• Miki H, Yamaguchi H, Suetsugu S, Takenawa T . IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. . Nature . 408 . 6813 . 732–5 . 2001 . 11130076 . 10.1038/35047107 . 2000Natur.408..732M . 4426046 .
• Marchand JB, Kaiser DA, Pollard TD, Higgs HN . Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. . Nat. Cell Biol. . 3 . 1 . 76–82 . 2001 . 11146629 . 10.1038/35050590 . 30437883 .
• Millard TH, Machesky LM . The Wiskott–Aldrich syndrome protein (WASP) family. . Trends Biochem. Sci. . 26 . 3 . 198–9 . 2001 . 11246027 . 10.1016/S0968-0004(01)01788-1 .
• Worby CA, Simonson-Leff N, Clemens JC, etal . Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. . J. Biol. Chem. . 277 . 11 . 9422–8 . 2002 . 11773052 . 10.1074/jbc.M110172200 . free .
• Miki H, Takenawa T . WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. . Biochem. Biophys. Res. Commun. . 293 . 1 . 93–9 . 2002 . 12054568 . 10.1016/S0006-291X(02)00218-8 .
• Eden S, Rohatgi R, Podtelejnikov AV, etal . Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. . Nature . 418 . 6899 . 790–3 . 2002 . 12181570 . 10.1038/nature00859 . 2002Natur.418..790E . 4350733 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Innocenti M, Zucconi A, Disanza A, etal . Abi1 is essential for the formation and activation of a WAVE2 signalling complex. . Nat. Cell Biol. . 6 . 4 . 319–27 . 2004 . 15048123 . 10.1038/ncb1105 . 22767022 .

Notes and References

1. Suetsugu S, Miki H, Takenawa T . Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex . Biochem Biophys Res Commun . 260 . 1 . 296–302 . July 1999. 10381382 . 10.1006/bbrc.1999.0894 .
2. 10381382 . 10.1006/bbrc.1999.0894 . 260 . Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex . June 1999 . Biochem. Biophys. Res. Commun. . 296–302 . Suetsugu S, Miki H, Takenawa T. 1 .
3. Web site: Entrez Gene: WASF2 WAS protein family, member 2.
4. Miki . H . Yamaguchi H . Suetsugu S . Takenawa T . December 2000. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling . . 408 . 6813 . 732–5 . 0028-0836. 11130076 . 10.1038/35047107 . 2000Natur.408..732M . 4426046 .