Infectious pancreatic necrosis birnavirus Vp4 peptidase explained

Infectious pancreatic necrosis birnavirus Vp4 peptidase
Ec Number:	3.4.21.115

Infectious pancreatic necrosis birnavirus Vp4 peptidase (infectious pancreatic necrosis virus protease, IPNV Vp4 protease, IPNV Vp4 peptidase, NS protease, NS-associated protease, Vp4 protease) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleaves the (Ser/Thr)-Xaa-Ala-(Ser/Ala)-Gly motif in the polyprotein NH₂-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions

Infectious pancreatic necrosis virus is a birnavirus that causes an acute, contagious disease in young salmonid fish.

Notes and References

1. Manning DS, Leong JC . Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus . Virology . 179 . 1 . 16–25 . November 1990 . 2219718 . 10.1016/0042-6822(90)90268-v .
2. Petit S, Lejal N, Huet JC, Delmas B . Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus . Journal of Virology . 74 . 5 . 2057–66 . March 2000 . 10666235 . 111686 . 10.1128/jvi.74.5.2057-2066.2000 .
3. The molecular biology of infectious pancreatic necrosis virus (IPNV) . Dobos, P. . Annu. Rev. Fish Dis. . 1995 . 5 . 25–54 . 10.1016/0959-8030(95)00003-8.