Voacristine Explained

Voacristine is a indole alkaloid occurring in Voacanga and Tabernaemontana genus. It is also an iboga type alkaloid.^[1]

Chemistry

Its structure is almost similar to voacangine, an alkaloid used in semi-synthesis of ibogaine. Compared to voacangine, it has an extra O-atom. When it is degraded, iboxygaine and ibogaine are formed.^[2]

Sources

Voacristine is found in multiple species of Tabernaemontana including Tabernaemontana divaricata,^[3] Tabernaemontana heyneana,^[4] Tabernaemontana ventricosa,^[5] and Voacanga africana.^[6]

See also

• Heyneanine
• Voacamine
• Vobasine

Notes and References

1. Lo MW, Matsumoto K, Iwai M, Tashima K, Kitajima M, Horie S, Takayama H . Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum . . 65 . 1 . 157–65 . January 2011 . 21042867 . 10.1007/s11418-010-0478-6 . 25706616 .
2. Renner U, Prins DA . [Voacanga alkaloids. III. Voacristine: identity with voacangarine and decomposition to iboxygaine and ibogaine] . de . Experientia . 15 . 456–7 . December 1959 . 14437366 . 10.1007/BF02158249 . 26926236 .
3. Henriques AT, Melo AA, Moreno PR, Ene LL, Henriques JA, Schapoval EE . Ervatamia coronaria: chemical constituents and some pharmacological activities . . 50 . 1 . 19–25 . January 1996 . 8778503 . 10.1016/0378-8741(95)01328-8 .
4. Srivastava S, Singh MM, Kulshreshtha DK . A new alkaloid and other anti-implantation principles from Tabernaemontana heyneana . . 67 . 6 . 577–9 . August 2001 . 11509989 . 10.1055/s-2001-16495 . 260252763 .
5. Andima M, Ndakala A, Derese S, Biswajyoti S, Hussain A, Yang LJ, Akoth OE, Coghi P, Pal C, Heydenreich M, Wong VK, Yenesew A . Antileishmanial and cytotoxic activity of secondary metabolites from Taberneamontana ventricosa and two aloe species . . 36. 5. 1365–1369 . January 2021 . 33459049 . 10.1080/14786419.2021.1871906 . 231635212 .
6. Chen HM, Yang YT, Li HX, Cao ZX, Dan XM, Mei L, Guo DL, Song CX, Dai Y, Hu J, Deng Y . Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph . . 30 . 10 . 1144–9 . 2016 . 26140390 . 10.1080/14786419.2015.1046132 . 23406913 .