| Official Name: | Vlierzele |
| Settlement Type: | Village |
| Pushpin Map: | Belgium |
| Pushpin Label Position: | left |
| Pushpin Map Caption: | Location in Belgium |
| Pushpin Mapsize: | 250 |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Type2: | Province |
| Subdivision Type3: | Municipality |
| Subdivision Name: |  |
| Subdivision Name1: | Flemish Region |
| Subdivision Name2: | East Flanders |
| Subdivision Name3: | Sint-Lievens-Houtem |
| Area Total Km2: | 6.23 |
| Population As Of: | 2021 |
| Population Footnotes: | [1] |
| Population Total: | 2,169 |
| Population Density Km2: | auto |
| Timezone: | CET |
| Coordinates: | 50.9333°N 57°W |
Vlierzele is a village on the Molenbeek, in the Denderstreek, at the edge of the Flemish Ardennes, the hilly southern part of East Flanders, Belgium. It belongs to the municipality of Sint-Lievens-Houtem.
Etymologically the name Vlierzele is derived from Fliteritsale (in 639) and Vliendersele (in 1412). This is a combination of either the plant name "vlier", which is Dutch for "elder", or the person's name Flether, and "sale" or "sele", which both mean place of residence in Old-Dutch.[2]
The neighbouring villages are: