Vitamin D3 dihydroxylase explained
| Vitamin D3 dihydroxylase |
| Organism: | Streptomyces griseolus |
| Taxid: | 1909 |
| Symbol: | CYP105A1 |
| Altsymbols: | VD3 hydroxylase, Cytochrome P450-SU1 |
| Uniprot: | P18326 |
| Ecnumber: | 1.14.15.22 |
Vitamin D3 dihydroxylase is a cytochrome P450 enzyme purified from the actinobacterium Streptomyces griseolus,[1] with EC number and CYP Symbol CYP105A1 (Cytochrome P450, family 105, member A1), catalyses oxidation of cholecalciferol(vitamin D3) to calcitriol.[2]
Notes and References
- O'Keefe DP, Romesser JA, Leto KJ . Identification of constitutive and herbicide inducible cytochromes P-450 in Streptomyces griseolus. . Archives of Microbiology . March 1988 . 149 . 5 . 406–12 . 10.1007/BF00425579 . 1988ArMic.149..406O . 35526991 .
- Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K . Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1 . Biochemical and Biophysical Research Communications . 320 . 1 . 156–64 . July 2004 . 15207715 . 10.1016/j.bbrc.2004.05.140 .
